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\n\u3068\u3053\u308d\u304c\u3001\u3053\u306e\u5927\u5207\u306a\u6297\u9178\u5316\u53cd\u5fdc\u3082\u3001\u9ad8\u8840\u7cd6\u3084\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u306a\u3069\u306b\u3088\u308a\u90aa\u9b54\u3055\u308c\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u3002\u305f\u3068\u3048\u3070\u9ad8\u8840\u7cd6\u304c\u3042\u308b\u3068\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u3078\u3070\u308a\u3064\u304d\u3001SOD\u306a\u3069\u306e\u9175\u7d20\u306e\u50cd\u304d\u3092\u963b\u5bb3\u3057\u305f\u308a\u3059\u308b\u306e\u3067\u3059\u3002
\n\u305d\u3057\u3066\u3001\u9178\u5316\u53cd\u5fdc\u304c\u6297\u9178\u5316\u53cd\u5fdc\u3088\u308a\u3082\u5927\u304d\u3044\u72b6\u614b\u304c\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306a\u306e\u3067\u3059\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u305b\u3044\u3067\u3001\u4eba\u306e\u8eab\u4f53\u306b\u306f\u3055\u307e\u3056\u307e\u306a\u60aa\u5f71\u97ff\u304c\u3082\u305f\u3089\u3055\u308c\u3066\u3057\u307e\u3044\u307e\u3059\u3002
\n\u73fe\u5728\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306f\u3001\u8001\u5316\u3001\u304c\u3093\u3001\u52d5\u8108\u786c\u5316\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u7cd6\u5c3f\u75c5\u5408\u4f75\u75c7\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306a\u3069\u3001\u5acc\u306a\u6162\u6027\u75c5\u307b\u3068\u3093\u3069\u306e\u5143\u51f6\u3067\u306f\u306a\u3044\u304b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u9006\u306b\u3001\u7cd6\u8cea\u3092\u6e1b\u3089\u305b\u3070\u3001\u304c\u3093\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u306a\u3069\u306e\u4e88\u9632\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u6975\u3081\u3066\u9ad8\u3044\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308b\u306e\u3067\u3059\u3002
\n\u4e2d\u9ad8\u5e74\u306b\u306a\u3063\u3066\u304f\u308b\u3068\u57fa\u790e\u4ee3\u8b1d\u3082\u843d\u3061\u3001\u904b\u52d5\u91cf\u3082\u5c11\u306a\u304f\u306a\u308a\u3001SOD\u3082\u6e1b\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u5e74\u9f62\u304c\u4e0a\u306b\u306a\u308c\u3070\u306a\u308b\u307b\u3069\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u5fdc\u3059\u308b\u529b\u304c\u5f31\u304f\u306a\u308b\u306e\u3067\u3059\u3002
\n\u57fa\u790e\u4ee3\u8b1d\u304c\u843d\u3061\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u7b4b\u8089\u304c\u6e1b\u3063\u3066\u30d6\u30c9\u30a6\u7cd6\u306e\u53d6\u308a\u8fbc\u307f\u304c\u5f31\u304f\u306a\u308b\u3068\u3044\u3046\u3053\u3068\u306a\u306e\u3067\u3059\u3002\u305d\u306e\u305f\u3081\u8840\u7cd6\u5024\u304c\u4e0a\u304c\u308c\u3070\u3001\u3055\u3089\u306bSOD\u306e\u50cd\u304d\u304c\u969c\u5bb3\u3055\u308c\u307e\u3059\u3002
\n\u3060\u304b\u3089\u3053\u305d\u3001\u8840\u7cd6\u5024\u3092\u4e0a\u3052\u306a\u3044\u98df\u4e8b\uff08\u7cd6\u8cea\u5236\u9650\uff09\u304c\u3001\u4e2d\u9ad8\u5e74\u304b\u3089\u306e\u5065\u5eb7\u306b\u306f\u307e\u3059\u307e\u3059\u91cd\u8981\u5ea6\u3092\u5897\u3059\u3053\u3068\u306b\u306a\u308b\u306e\u3067\u3059\u3002\u7cd6\u8cea\u5236\u9650\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6e1b\u3089\u3059\u306e\u3067\u3059\u3002<\/p>\n

\u3082\u30461\u3064\u3001\u7cd6\u8cea\u5236\u9650\u306e\u6709\u52b9\u6027\u3092\u7406\u89e3\u3059\u308b\u306e\u306b\u91cd\u8981\u306a\u30ad\u30fc\u30ef\u30fc\u30c9\u304c\u3001\u300cAGEs\uff08\u30a8\u30fc\u30b8\u30fc\u30a4\u30fc\u30ba\uff09\uff1a\u7d42\u672b\u7cd6\u5316\u7523\u7269\u300d\u3067\u3059\u3002
\n\u305f\u3068\u3048\u3070\u300110\u5e74\u9593\u7cd6\u5c3f\u75c5\u3067\u9ad8\u8840\u7cd6\u306e\u72b6\u614b\u306b\u3042\u3063\u305f\u4eba\u304c\u3001\u6700\u8fd1\u306b\u306a\u3063\u3066\u7cd6\u8cea\u5236\u9650\u98df\u3092\u59cb\u3081\u3066\u8840\u7cd6\u5024\u304c\u5b8c\u5168\u306b\u6b63\u5e38\u306b\u306a\u3063\u305f\u3068\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u305d\u308c\u3067\u3082\u30012\u5e74\u5f8c\u306b\u52d5\u8108\u786c\u5316\u306b\u3088\u308b\u5408\u4f75\u75c7\u306b\u306a\u308b\u3088\u3046\u306a\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002
\n\u3053\u308c\u306f\u3001\u8840\u7cd6\u5024\u306e\u9ad8\u304b\u3063\u305f10\u5e74\u9593\u3067\u751f\u307f\u51fa\u3055\u308c\u305fAGEs\u304c\u3001\u3059\u3067\u306b\u52d5\u8108\u786c\u5316\u3092\u8d77\u3053\u3057\u3066\u304a\u308a\u3001\u8840\u7cd6\u304c\u6b63\u5e38\u306b\u306a\u3063\u305f\u5f8c\u3067\u3082\u6b8b\u3063\u3066\u3057\u307e\u3046\u304b\u3089\u3067\u3059\u3002\u3053\u306e\u52d5\u8108\u786c\u5316\u306e\u5b58\u5728\u304c\u3001\u5408\u4f75\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3057\u307e\u3046\u304b\u3089\u3067\u3059\u3002
\n\u3053\u306e\u3088\u3046\u306b\u3001\u304b\u3064\u3066\u306e\u9ad8\u8840\u7cd6\u304c\u305a\u3063\u3068\u5f8c\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u304c\u3042\u308a\u3001\u3053\u306e\u73fe\u8c61\u306f\u300c\u9ad8\u8840\u7cd6\u306e\u8a18\u61b6\u300d\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002
\n\u305f\u3068\u3048\u308c\u3070\u3001\u73fe\u5728\u306f\u9ed2\u5b57\u306e\u4f1a\u793e\u306b\u3001\u904e\u53bb\u306e\u5927\u304d\u306a\u501f\u91d1\u304c\u6b8b\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u4eca\u3082\u82e6\u3057\u307e\u306a\u3051\u308c\u3070\u3044\u3051\u306a\u3044\u306e\u3068\u540c\u3058\u3067\u3059\u3002
\n\u5f8c\u3005\u307e\u3067\u6b8b\u308a\u7d9a\u3051\u308bAGEs\u306e\u60aa\u5f71\u97ff\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u4eba\u306b\u3060\u3051\u95a2\u4fc2\u306e\u3042\u308b\u8a71\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u3063\u305f\u304f\u5065\u5eb7\u306a\u4eba\u306e\u5834\u5408\u3067\u3082\u3001\u666e\u901a\u306b\u7cd6\u8cea\u3092\u98df\u3079\u308c\u3070\u3001160\u338e\uff0fdl\u3092\u8d85\u3048\u308b\u9ad8\u8840\u7cd6\u306b\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u8840\u7cd6\u5024\u304c\u9ad8\u3044\u307b\u3069\u3001\u305d\u3057\u3066\u671f\u9593\u304c\u9577\u3044\u307b\u3069AGEs\u306f\u84c4\u7a4d\u3057\u3066\u3044\u304d\u307e\u3059\u3002
\n\u4eca\u306f\u5065\u5eb7\u4f53\u3067\u3082\u3001\u6bce\u65e5\u306e\u98df\u751f\u6d3b\u3067\u77e5\u3089\u306a\u3044\u3046\u3061\u306b\u5168\u8eab\u306e\u8840\u7ba1\u306bAGEs\u3092\u305f\u3081\u3066\u3057\u307e\u3063\u3066\u3044\u308b\u4eba\u304c\u591a\u304f\u3044\u308b\u306f\u305a\u3067\u3059\u3002\u3059\u3067\u306b50\u5e74\u4ee5\u4e0a\u3082\u4eba\u751f\u3092\u9001\u3063\u3066\u3044\u308b\u4eba\u306a\u3089\u3070\u3001\u8ab0\u3067\u3082\u3001AGEs\u306b\u3088\u3063\u3066\u52d5\u8108\u786c\u5316\u306b\u306a\u308b\u30ea\u30b9\u30af\u304c\u3042\u308b\u306e\u3067\u3059\u3002
\n\u306a\u308b\u3079\u304f\u65e9\u304f\u7cd6\u8cea\u5236\u9650\u3092\u59cb\u3081\u3001AGEs\u306e\u84c4\u7a4d\u3092\u6b62\u3081\u308b\u3079\u304d\u3067\u3057\u3087\u3046\u3002<\/p>\n

\u76ae\u819a\u306e\u7cd6\u5316\u5ea6\u3092\u6e2c\u5b9a\u3059\u308b\u3068\u3001\u8001\u5316\u306e\u5177\u5408\u304c\u3088\u304f\u308f\u304b\u308a\u307e\u3059\u3002\u76ae\u819a\u306e\u7cd6\u5316\u5ea6\u304c\u9ad8\u3044\u3068\u3001\u3057\u308f\u304c\u591a\u304f\u306a\u308a\u660e\u3089\u304b\u306b\u8276\uff08\u3064\u3084\uff09\u304c\u306a\u304f\u306a\u308a\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u76ae\u819a\u304c\u8001\u5316\u3057\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002
\nAGEs\u304c\u84c4\u7a4d\u3057\u3066\u7cd6\u5316\u5ea6\u304c\u9032\u3093\u3067\u3044\u308b\u3068\u3001\u3053\u308c\u3068\u540c\u3058\u3053\u3068\u304c\u5168\u8eab\u3067\u8d77\u3053\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u3002AGEs\u306f\u6d88\u3048\u306a\u3044\u501f\u91d1\u306e\u3088\u3046\u306a\u5b58\u5728\u3067\u3001\u65b0\u9673\u4ee3\u8b1d\u3067\u66f4\u65b0\u3055\u308c\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u306e\u91cf\u304c\u591a\u3044\u307b\u3069\u8001\u5316\u304c\u9032\u3093\u3067\u3044\u308b\u308f\u3051\u3067\u3059\u3002
\n\u3064\u307e\u308a\u3001\u8001\u5316\u306e\u5143\u51f6\u306e1\u3064\u306fAGEs\u3001\u7cd6\u5316\u306a\u306e\u3067\u3059\u3002
\n\u82e5\u3044\u6642\u304b\u3089\u7cd6\u8cea\u5236\u9650\u3092\u59cb\u3081\u308c\u3070\u3001\u65e9\u3044\u3046\u3061\u306b\u8001\u5316\u3092\u6b62\u3081\u3089\u308c\u308b\u306e\u3067\u3059\u3002
\n\u306a\u304a\u8001\u5316\u306e\u5143\u51f6\u306e\u3082\u30461\u3064\u306f\u3001\u524d\u8ff0\u306e\u3088\u3046\u306b\u904e\u5270\u306a\u6d3b\u6027\u9178\u7d20\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3067\u3059\u3002\u3053\u3061\u3089\u3082\u7cd6\u8cea\u5236\u9650\u98df\u3067\u9ad8\u8840\u7cd6\u3068\u9ad8\u30a4\u30f3\u30b9\u30ea\u30f3\u8840\u75c7\u3092\u9632\u3052\u3070\u3001\u6d3b\u6027\u9178\u7d20\u306e\u767a\u751f\u304c\u6e1b\u308b\u306e\u3067\u3042\u308b\u7a0b\u5ea6\u4e88\u9632\u3067\u304d\u307e\u3059\u3002
\n\u7cd6\u8cea\u5236\u9650\u3092\u59cb\u3081\u308b\u306e\u306b\u91cd\u8981\u306a\u306e\u306f50\u4ee3\u3067\u3059\u300250\u4ee3\u306a\u3089\u3070\u3001\u307e\u3060\u3001\u8001\u5316\u7269\u8cea\u3067\u3042\u308bAGEs\u306f\u53d6\u308a\u8fd4\u3057\u306e\u3064\u304b\u306a\u3044\u307b\u3069\u306b\u306f\u305f\u307e\u3063\u3066\u3044\u307e\u305b\u3093\u304b\u3089\u3001\u7cd6\u8cea\u5236\u9650\u3067\u3053\u308c\u4ee5\u4e0a\u306e\u84c4\u7a4d\u3092\u98df\u3044\u6b62\u3081\u3089\u308c\u308b\u304b\u3089\u3067\u3059\u3002
\n50\u4ee3\u306a\u3089\u307e\u3060\u3001\u9593\u306b\u5408\u3046\u306e\u3067\u3059\u3002
\n\u3057\u304b\u3057\u3001\u3053\u308c\u3088\u308a\u3082\u9ad8\u9f62\u306b\u306a\u308b\u3068\u3001\u304b\u306a\u308a\u306e\u91cf\u306eAGEs\u304c\u305f\u307e\u3063\u3066\u304a\u308a\u3001\u8001\u5316\u304c\u8eab\u4f53\u3092\u8755\uff08\u3080\u3057\u3070\uff09\u3093\u3067\u3057\u307e\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u3044\u3063\u305f\u3093\u305f\u307e\u3063\u305fAGEs\u306f\u3082\u3046\u6d88\u3048\u307e\u305b\u3093\u3002
\n\u3064\u307e\u308a\u300150\u4ee3\u3067\u8001\u5316\u7269\u8cea\u306e\u84c4\u7a4d\u3092\u6b62\u3081\u3089\u308c\u308b\u304b\u3069\u3046\u304b\u3067\u3001\u305d\u306e\u5f8c\u306e\u4eba\u751f\u304c\u6c7a\u307e\u308b\u3068\u8a00\u3063\u3066\u3082\u904e\u8a00\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u300250\u4ee3\u3053\u305d\u7cd6\u8cea\u5236\u9650\u3092\u59cb\u3081\u308b\u3079\u304d\u6642\u671f\u306a\u306e\u3067\u3059\u3002
\n\u3057\u304b\u3057\u3001\u6b8b\u5ff5\u306a\u304c\u3089\u3001\u591a\u304f\u306e\u4e2d\u9ad8\u5e74\u304c\u7cd6\u8cea\u5236\u9650\u306b\u3042\u307e\u308a\u71b1\u5fc3\u3067\u306a\u3044\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002
\n\u305d\u306e\u7406\u7531\u306f\u3044\u304f\u3064\u304b\u3042\u308b\u3088\u3046\u3067\u3059\u3002
\n\u307e\u305a\u3001\u7279\u306b\u7537\u6027\u306b\u591a\u3044\u306e\u3067\u3059\u304c\u3001\u4ed5\u4e8b\u304c\u5fd9\u3057\u3059\u304e\u308b\u3068\u3044\u3046\u4eba\u304c\u3044\u307e\u3059\u3002\u305f\u3057\u304b\u306b\u300150\u4ee3\u3068\u3044\u3046\u3068\u793e\u4f1a\u7684\u306a\u8cac\u4efb\u306e\u91cd\u3044\u4e16\u4ee3\u3067\u3059\u304b\u3089\u3001\u5065\u5eb7\u3092\u758e\uff08\u304a\u308d\u305d\uff09\u304b\u306b\u3057\u304c\u3061\u306b\u306a\u308b\u306e\u3082\u7121\u7406\u304b\u3089\u306c\u3068\u3053\u308d\u304c\u3042\u308b\u3067\u3057\u3087\u3046\u3002
\n\u307e\u305f\u3001\u7cd6\u8cea\u5236\u9650\u306b\u61d0\u7591\u7684\u306a\u4eba\u3082\u3044\u307e\u3059\u3002
\n\u3053\u308c\u306f\u5973\u6027\u306b\u3082\u591a\u3044\u306e\u3067\u3059\u304c\u3001\u5065\u5eb7\u60c5\u5831\u306b\u8a73\u3057\u3044\u3068\u3044\u3046\u30bf\u30a4\u30d7\u306b\u591a\u3044\u3088\u3046\u3067\u3059\u3002
\n\u60c5\u5831\u904e\u591a\u306e\u73fe\u4ee3\u3067\u306f\u3001\u7cd6\u8cea\u5236\u9650\u306b\u95a2\u3059\u308b\u8aa4\u89e3\u304c\u8513\u5ef6\u3057\u3066\u3044\u3066\u3001\u305d\u306e\u6709\u52b9\u6027\u3092\u6b63\u3057\u304f\u8a8d\u8b58\u3057\u3066\u3044\u306a\u3044\u5834\u5408\u3082\u3042\u308b\u306e\u3067\u3059\u3002
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